Understanding Zika Virus Stability and Developing a Chimeric Vaccine through Functional Analysis
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چکیده
منابع مشابه
Understanding Zika Virus Stability and Developing a Chimeric Vaccine through Functional Analysis
Compared with other flaviviruses, Zika virus (ZIKV) is uniquely associated with congenital diseases in pregnant women. One recent study reported that (i) ZIKV has higher thermostability than dengue virus (DENV [a flavivirus closely related to ZIKV]), which might contribute to the disease outcome; (ii) the higher thermostability of ZIKV could arise from an extended loop structure in domain III o...
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Current prevention strategies fo cus on mosquito control, protec tion of the blood supply, barrier protection during sex, and other forms of contraception. When this explosive epidemic abates, Zika vi rus could remain endemic in many countries, where the risk to preg nant women, the general public, and travelers will persist. There fore, a safe and effective vaccine is essential. Developme...
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ژورنال
عنوان ژورنال: mBio
سال: 2017
ISSN: 2161-2129,2150-7511
DOI: 10.1128/mbio.02134-16